Abstract
26 patients with louse-borne relapsing fever (L.B.R.F.) and 10 others with serologically proven epidemic typhus were treated with a single oral dose of 100 mg. of doxycycline. All patients were cured and no relapses of L.B.R.F. or typhus occurred during the 2-week period of posttreatment observation. Each of the L.B.R.F. patients experienced a Jarisch-Herxheimer reaction following treatment, which was complicated by hypotension and/or cardiac failure in 5 patients. This was successfully treated with intravenous digoxin. The difficulty of diagnosing typhus and differentiating it from enteric fevers may restrict the use of single-dose doxycycline to epidemics or to mass-treatment campaigns directed at eradicating the human reservoirs of these infections.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
