Abstract
BackgroundAcarbose slows down the intestinal absorption of carbohydrates, but its effects on the secretion of incretins are still poorly known. This study aimed to examine the effects of single-dose acarbose on the secretion of incretins in patients with newly diagnosed type 2 diabetes mellitus (T2DM).MethodsIn this pilot study, twenty-three patients diagnosed with T2DM were randomly assigned to the oral glucose tolerance test (OGTT) group (n = 11) and the mixed meal test (MMT) group (n = 12). Fourteen subjects with normal OGTT were included as controls. Plasma glucose, insulin, glucagon, glucagon-like peptide-1 (GLP-1), and glucose-dependent insulinotropic peptide (GIP) were measured at 0 (fasting), 15, 30, 60, 90, and 120 min after nutrient load. A week later, controls underwent MMT, the OGTT group underwent OGTT receiving 100 mg acarbose, and the MMT group underwent MMT receiving 100 mg acarbose. The same blood markers were measured again.ResultsNo significant difference was observed in the OGTT group before and after administering acarbose. In the MMT group, postprandial levels of glucose (P < 0.01), insulin (P < 0.01), glucagon at 15 min (P < 0.05), glucagon area under the curve (AUC) (P < 0.05), GIP levels at 30 min (P < 0.05), and GIP AUC (P < 0.05) were decreased after receiving acarbose with a mixed meal, but GLP-1 levels and GLP-1 AUC did not change.ConclusionsSingle-dose acarbose could reduce the secretion of GIP and glucagon after a mixed meal in patients with newly diagnosed T2DM. The influence of acarbose on incretin levels could be related to the types of carbohydrate being consumed.Trial registrationThis study was registered with the Chinese Clinical Trial Registry (Registration Number: ChiCTR-TRC-14004260, Date of Registration: 2014-01-19).
Highlights
Acarbose slows down the intestinal absorption of carbohydrates, but its effects on the secretion of incretins are still poorly known
Studies have demonstrated that an impaired secretion of incretins in patients with type 2 diabetes mellitus (T2DM) is characterized by a decreased secretion of glucagon-like peptide-1 (GLP-1) after a mixed meal, resulting in the dysfunction of insulinotropic actions, or a total loss of glucosedependent insulinotropic peptide (GIP) effect even with normal levels [4]
The present study aimed to identify whether a single dose of acarbose had the potential to affect incretin levels beyond its glycemic effect in drug-naive Chinese patients newly diagnosed with T2DM
Summary
Acarbose slows down the intestinal absorption of carbohydrates, but its effects on the secretion of incretins are still poorly known. This study aimed to examine the effects of single-dose acarbose on the secretion of incretins in patients with newly diagnosed type 2 diabetes mellitus (T2DM). Considerable evidence suggests that incretin dysfunction accompanies the development of type 2 diabetes mellitus (T2DM). Studies have demonstrated that an impaired secretion of incretins in patients with T2DM is characterized by a decreased secretion of GLP-1 after a mixed meal, resulting in the dysfunction of insulinotropic actions, or a total loss of GIP effect even with normal levels [4]. Many factors may affect incretin secretion including meal composition, obesity, insulin resistance, glucose intolerance, gastricemptying, and glucose-lowering drugs [5], and their exact relationships are still poorly known
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
