Abstract

Aims: Phenotypic heterogeneity allows individual cells to behave different from the bulk. This non-genetic variability provides a critical route to therapeutic resistance and relapse of cancer. Herein, we characterize phenotypic dynamics that generate an intrinsic and pre-existent, drug-tolerant state and identify a resistance biomarker profile to detect these ‘persister’ cells in skin lesions of CTCL.

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