Single-cell, Multi-omic Analysis of Peanut-reactive CD4+ T Cells Identifies Gene Signatures Favorable for Sustained Unresponsiveness Following Peanut Oral Immunotherapy

Abstract

Peanut-reactive (pr) CD4+ T cells are pivotal for the onset of peanut allergy as well as for peanut oral immunotherapy (OIT)-induced desensitization (DS). However, the underlying immune mechanism of how pr CD4+ T cells impact the development of sustained unresponsiveness (SU) following a period of avoidance is largely unknown. To this end, we probed pr CD4+ T cells from the phase 2 peanut OIT trial- POISED participants, who achieved SU vs. those who did not (termed as SU and DS participants respectively based on no vs.