Abstract
A single tumor mass is comprised of many different subpopulations of cells. During evolutionary trajectory of a tumor, cells with different molecular features are likely to evolve and interactions between these heterogenous cell subpopulations in tumor are highly dynamic..
Highlights
A single tumor mass is comprised of many different subpopulations of cells
Most research on single-cell omics and multi-omics techniques have been consisted of proof-of-concept studies, and publications reporting the application of these methods in various aspects of cancer research are just beginning to emerge
With rapid advances in the field and reducing costs to perform such studies, increasing number of cancer researchers will employ these techniques in their field of study
Summary
A single tumor mass is comprised of many different subpopulations of cells. During evolutionary trajectory of a tumor, cells with different molecular features are likely to evolve and interactions between these heterogenous cell subpopulations in tumor are highly dynamic [1]. With these single cell epigenomics tools, it is possible to study a single cancer cell in terms of all forms of epigenetic regulation (for example, DNA methylation, chromatin accessibility, histone modifications and 3D chromatin topology).
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