Abstract
Near-infrared (NIR) fluorescence imaging systems have been developed for image guided surgery in recent years. However, current systems are typically bulky and work only when surgical light in the operating room (OR) is off. We propose a single camera imaging system that is capable of capturing NIR fluorescence and color images under normal surgical lighting illumination. Using a new RGB-NIR sensor and synchronized NIR excitation illumination, we have demonstrated that the system can acquire both color information and fluorescence signal with high sensitivity under normal surgical lighting illumination. The experimental results show that ICG sample with concentration of 0.13 μM can be detected when the excitation irradiance is 3.92 mW/cm2 at an exposure time of 10 ms.
Highlights
Near-infrared (NIR) fluorescence imaging techniques have been developed for a number of clinical applications, ranging from improving tumor delineation, sentinel lymph node identification, and metastasis staging, to neuronal activity monitoring [1]
Near-infrared (NIR) fluorescence imaging systems have been developed for image guided surgery in recent years
We propose a single camera imaging system that is capable of capturing NIR fluorescence and color images under normal surgical lighting illumination
Summary
Near-infrared (NIR) fluorescence imaging techniques have been developed for a number of clinical applications, ranging from improving tumor delineation, sentinel lymph node identification, and metastasis staging, to neuronal activity monitoring [1]. One common issue of current fluorescence image guided surgical systems is that the surgical light has to be turned off or dimed significantly to improve fluorescence image contrast [1, 13,14,15]. To address this problem, Sexton et al presented a fluorescence guided surgery system using pulsed excitation and gated acquisition [13]. Sexton et al presented a fluorescence guided surgery system using pulsed excitation and gated acquisition [13] This approach works well under the normal surgical lighting condition, it is relatively complicated because a fast filter wheel is needed to work with pulsed excitation. We propose a novel single camera color and NIR fluorescence imaging system that is capable of capturing color and fluorescence images under normal surgical lighting illumination, using a single RGB-NIR camera and synchronized excitation illumination
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