SINGLE BLIND PLACEBO-BASED STUDY ON PREVENTION OF CORONARY ARTERY DISEASE (CAD) BY INJEER AND ISPAGHULA

Abstract

Introduction: Injeer and Ispaghula are frequently/successfully used for treatment of both primary and secondary Hyperlipidemia. Major cardiac diseases are directly or indirectly linked with high levels of lipids in systemic circulation. Various medicinal herbs can normalize lipid profile of patients suffering from primary or secondary hyperlipidemia with or without metabolic syndrome. Place of research work: It was conducted at Jinnah hospital Lahore-Pakistan from January to May 2016. One hundred hyperlipidemic patients were enrolled for the research work. Type of research study: This research work was single blind placebo-controlled. Criteria for inclusion and exclusion: Primary or secondary hyperlipidemic patients of both gender, age range from 20 to 65 years were included in research. Patients suffering from any major organ disease like renal, hepatic, pulmonary diseases and already on drugs for major cardiac disease were excluded from the study. Grouping of participants: Patients were divided in four groups, 25 patients in each group. Group-I was on Injeer, Group-II was on Ispaghula, Group-III was on combination of these two herbal medicines, and Group-IV was considered as control group. Determination of TC, TG, LDL-C and HDL-C: Base line lipid profile was measured in Pathology Laboratory of JINNAH HOSPITAL. Result compilation and biostatistical analysis: After three months therapy, their lipid profile was determined and mean values with ±SEM were compared before and after treatment. When analyzed statistically and compared with placebo effects, all patients’ LDL-cholesterol was reduced significantly. HDL-cholesterol was increased in all groups of patient. Conclusion: Final conclusion of research work was that at specific concentration and period of ingestion of herbs like psyllium husk, and figs can reduce risk of hyperlipidemia leading to development of cardiac diseases, especially coronary artery disease.