Single-Atom Indium Boosts Electrochemical Dopamine Sensing.

Abstract

A rational design of high-efficiency electrocatalysts and thus achieving sensitive electrochemical sensing remains a great challenge. In this work, single-atom indium anchored on nitrogen-doped carbon (In1-N-C) with an In-N4 configuration is prepared successfully through a high-temperature annealing strategy; the product can serve as an advanced electrocatalyst for sensitive electrochemical sensing of dopamine (DA). Compared with In nanoparticle catalysts, In1-N-C exhibits high catalytic performance for DA oxidation. The theoretical calculation reveals that In1-N-C has high adsorption energy for hydroxy groups and a low energy barrier in the process of DA oxidation compared to In nanoparticles, indicating that In1-N-C with atomically dispersed In-N4 sites possesses enhanced intrinsic activity. An electrochemical sensor for DA detection is established as a concept application with high sensitivity and selectivity. Furthermore, we also verify the feasibility of In1-N-C catalysts for the simultaneous detection of uric acid, ascorbic acid, and DA. This work extends the application prospect of p-block metal single-atom catalysts in electrochemical sensing.