Abstract
RESUME: Background: Capecitabine is an oral fluoropyrimidine carbamate that is at least as effective than Fluorouracil / Leucovorin as first- line treatment for patients with metastatic colorectal cancer /CRC/. Aim: The aim of this study was to evaluate the efficacy and toxicity of single- agent Capecitabine as first- line therapy in patients with metastatic CRC. Methods: In the period 2007- 2009 17 consecutive patients with /CRC/ entered the study. The treatment schedule consists of Capecitabine 1250 mg/m 2 p.o. twice daily for 14 days with a 7- day rest period. Results: Overall response rate was 23,6% with one complete remission. Median survival was 12,4 months. Nausea, vomiting and diarrhea were the most common side effects. Conclusions: That data suggest that singleagent Capecitabine will offer opportunity to treat patients with advanced /CRC/.
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