Abstract
In contrast to its effects on Sindbis virus production in vertebrate cell cultures, actinomycin D was found to inhibit the production of virus in cultured Aedes albopictus cells and Bombyx mori cells. One to two hours of incubation in the presence of actinomycin D was required for the inhibition to be observed. Synthesis and processing of virus structural polypeptides were found to be normal during the period of arrest of virus production. These data are interpreted as indicating the presence of a labile host function involved in the assembly of Sindbis virus components into mature virus in invertebrate host cells.
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