Sinapic acid restores blood parameters, serum antioxidants, and liver and kidney functions in obesity.

Abstract

Obesity is an additional body fat that causes a harmful effect on human health while sinapic acid (SA) is a phyto-constituent presents in spices, citrus, berry fruits, and vegetables. This study evaluates SA to amend blood parameters, serum glucose, proteins, lipids, and antioxidants, and liver and kidney functions in obese rats. Thirty male albino rats were divided into 2 groups (normal and obese rats). The normal, non-obese rats subdivided into 2 subgroups; Control and SA (40mg/kg) subgroup: daily oral intake of 1ml saline and 40mg/kg SA, respectively once a day. The obese rats subdivided also into 3 subgroups; Obese, Obese + SA (20mg/kg), and Obese + SA (40mg/kg)-treated groups which received no treatment, 20mg/kg SA, and 40mg/kg SA, respectively once a day. All treatments were orally administrated for 1month. The results showed that obesity caused an increase in body and organ weight, serum total cholesterol, triglycerides, low density lipoproteins, malondialdehyde, nitric oxide, glucose, bilirubin and blood urea nitrogen while decrease serum superoxide dismutase, glutathione peroxidase, glutathione, glutathione reductase, glutathione-S-transferase, hemoglobin, hematocrite, red blood cells, white blood cells, aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, urea, creatinine, and uric acid compared to control group. Obesity caused disappearance of prothrombin and fibrinogen proteins and damages to liver and kidney tissues. The oral administration with SA daily for 1month in obese rats returned all these parameters to the control values where the higher dose of SA was more effective than the lower dose. In conclusion, SA restores body and organ weight, blood parameters, serum glucose, proteins, lipids, antioxidants, and liver and kidney functions in obesity.