Abstract
We report 2 cases of Sin Nombre virus (SNV) infection in field workers, possibly contracted through rodent bites. Screening for antibodies to SNV in rodents trapped in 2 seasons showed that 9.77% were seropositive. Quantitative real-time PCR showed that 2 of 79 deer mice had detectable titers of SNV RNA.
Highlights
We report 2 cases of Sin Nombre virus (SNV) infection in field workers, possibly contracted through rodent bites
Indoor exposure in poorly ventilated buildings has been reported as a major factor for contraction of hantavirus cardiopulmonary syndrome (HCPS), our survey supports the possibility that the 2 patients contracted SNV outdoors and that, in at least in 1 case, a rodent bite was the proximate vehicle for transmission of SNV to the field worker
The fact that patient 1 was bitten by a vole and not by a deer mouse does not necessarily exclude transmission of SNV by that route
Summary
We report 2 cases of Sin Nombre virus (SNV) infection in field workers, possibly contracted through rodent bites. She required oxygen supplementation but recovered almost completely by July 11 She reported performing fieldwork in the same period as did patient 1 but with no overlap among the sites (the distances between sampling sites where the 2 field workers most probably contracted their infections ranged from 6.4 to 9.8 km). Both patients engaged in field activities involving manipulating traps and rodents in areas where deer mice were seropositive for SNV (Table). Abundance, seropositivity, and Sin Nombre virus RNA quantification during May–June and August– September 2005, Boulder, Broomfield, and Jefferson counties, Colorado, USA*
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