Abstract
ABSTRACTObjective:Urinary stones with oxalate composition can cause kidney failure. Recent findings evidenced that probiotics are effective in reducing oxalate absorption in these subjects based on their high colonic absorption levels at baseline. The purpose of this study was to evaluate the effect of the simultaneous use of oxalate-degrading bacteria, Urtica dioica and T. terrestris extract in reducing urinary oxalate.Materials and Methods:Anti-urolithiatic activity of Urtica dioica and T. terrestris extract and probiotic by using ethylene glycol induced rat model. In this study, 4 strains of Lactobacillus and 2 strains of Bifidobacterium and also 2 strains of L. paracasei (that showed high power in oxalate degrading in culture media) were used. Male Wistar rats were divided into four groups (n=6). The rats of group-I received normal diet (positive control group) and groups-II (negative control group), III, IV rats received diet containing ethylene glycol (3%) for 30 days. Groups III rats received Urtica dioica and T. terrestris extract. Groups IV rats received extracts + probiotic for 30 days.Findings:The results show that the use of herbal extracts (Urtica dioica and T. terrestris) reduced the level of urinary oxalate and other parameters of urine and serum. Also, the accumulation of calcium oxalate crystals in the kidney tissue was significantly reduced.Conclusion:Considering that the formation of calcium oxalate crystals can cause inflammation and tissue damage in the kidney, the use of herbal extracts with oxalate degrading bacteria can be a new therapeutic approach to preventing the formation of kidney stones.
Highlights
Today, kidney stones represent an important health problem in many countries
On 30th days of the study period, concentrate urinary oxalate in the negative control group was significantly higher than in the intervention and positive control groups (p
Comparison of urinary oxalate concentrations in each group during the 30 days revealed that urinary oxalate concentrations in intervention groups decreased significantly on 30th day compared with the first day; in particular, in the intervention group the urinary oxalate concentration was normal
Summary
Kidney stones represent an important health problem in many countries. Genetic factors, metabolic disturbances (excess oxalate synthesis), food and environmental factors are among the most important causes of kidney stones, with 60-80% of human kidney stones induced by calcium oxalate [1, 2]. In 2001, Campieri orally prescribed a freeze-dried preparation composed of five organisms (Lactobacillus acidophilus, L. brevis, L. plantarum, Bifidobacterium infantis, and Streptococcus thermophiles) to a few hyperoxaluria patients for 30 days. These probiotics induced a significant decrease in oxalate excretion in the patients [19, 20].In addition, dietary supplementation with probiotic has emerged as a potential strategy to increase dietary oxalate degradation [21,22,23]. The purpose of our study was to evaluate the effect of simultaneous use of oxalate-degrading probiotic bacteria, Urtica dioica and T. terrestris extract in reducing urinary oxalate
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