Abstract
Amino acid sequences derived from the early (E) and late (L) coding regions of human papillomaviruses (HPV) type 6, 11, and 16 were analysed by means of a computer program for prediction of B-cell determinants. Eight peptides ranging from 9 to 17 amino acids and containing potential B-cell determinants were selected for synthesis. The peptides were synthesized by using a configuration for solid-phase synthesis that enables the simultaneous synthesis of several peptides in flow reactors at low pressure on standard poly(styrene-1% divinylbenzene)resin. Crude peptides were obtained in good yield and purity. They were then further purified by high-performance liquid chromatography for use as solid antigens in site-directed serology.
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