Abstract
In this work, a sensitive and selective spectrophotometric method was first introduced for the simultaneous determination of Salbutamol (SBT), Theophylline (TPL) and Ambroxol (ABX) in their ternary mixture without preliminary separation. Quantification was performed simply by zero-order spectrophotometric method at its λ max of 241, 224 and 245 nm for SBT, TPL and ABX respectively. The linear range was found to be 0.1–0.6 μg/ml for SBT, 5–30 μg/ml for TPL and 1.5–9.0 μg/ml for ABX that doesn't show any interference of other drugs even in low or high concentrations. The mean percentage recovery was found to be within the range of 98–102%. These methods were successfully applied to the analysis of their combined dosage form and bulk powder. The adopted methods were also statistically validated as per ICH guidelines.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
