Abstract

The analyst faces a couple of challenges when screening complex mixtures. Over the past decades, several strategies were developed to overcome these problems. The review presented here provides an overview of the different strategies on the integration of separation sciences, mass spectrometry, and bioactivity screening in a single platform to allow the simultaneous screening and characterization of complex mixtures. The applied strategies can generally be categorized into precolumn and postcolumn principles. While the precolumn methodologies mainly include affinity-based screening, the postcolumn strategies can also employ enzyme activity assays. The different subtypes of these philosophies will be discussed and examples for each of the techniques are presented.

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