Abstract
A hydrophilic drug (aspirin) and a hydrophobic drug (probucol), both widely used to treat restenosis, were incorporated into a quaternary ammonium salt-modified chitosan (HACC) using tripolyphosphate (TPP) as the crosslinker. Loading of the two drugs in the HACC nanoparticles was verified by Fourier transform infrared (FTIR) spectra. The physicochemical properties of the drug-loading nanoparticles were examined by differential scanning calorimetry (DSC) and zeta potential measurement. The aspirin and probucol in the HACC matrix existed in amorphous and crystalline phases, respectively. The release behaviors of the two drugs from the HACC nanoparticles were investigated. The HACC nanoparticles loaded with both drugs exhibited higher release rates and larger release amounts of the two drugs than the cases where they were loaded by aspirin or probucol alone. This study provides new insights into drug delivery systems.
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