Abstract
Abstract A simple liquid chromatographic procedure is presented for the simultaneous quantitation of three phenothiazine drugs, namely, perphenazine, trifluoperazine and triflupromazine and their sulphoxide degrades. The LC-separation was performed on a Novapak-phenyl-4 (150 × 3.9 mm id) column and a mobile phase composed of methanol + 1.5 × 10−2 M sodium acetate buffer pH 6.5 (81:19, v/v). Isocratic elution and UV-detection were adopted. Satisfactory percent assay and mean recoveries with low relative standard deviations were obtained for each drug and its sulphoxide in bulk and in tablet dosage form. The stability-indicating characteristics of the presented LC-procedure prove its advantage over the pharmacopeial methods used to limit the sulphoxides.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
More From: Journal of Liquid Chromatography & Related Technologies
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.