Abstract
BackgroundThe Chinese medicinal wine made from herbal medicines became prevalent among Chinese people. The Chinese herbal spirit is composed of several herbal extracts, and has the certain health functions, such as anti-fatigue and immune regulation. The quality evaluation of Chinese herbal spirit is greatly challenged by the enormous and complex components with great structural diversity and wide range of concentration distribution.MethodsAn ultra-high performance liquid chromatography coupled to triple quadrupole mass spectrometry (UHPLC-QQQ-MS/MS) with multiple reaction monitoring (MRM) method was developed to simultaneously determine forty-three bioactive components in the Chinese herbal spirits produced by year 2014 and 2018.ResultsQuantitative results showed that 11 components, i.e.., puerarin (5), purpureaside C (7), daidzin (8), echinacoside (9), acteoside (15), epimedin B (22), epimedin C (23), icariin (24), eugenol (27), chikusetsusaponin iva (30) and Z-ligustilide (40), significantly decreased along with the increasing years of storage, while 5 compounds, i.e.., geniposidic acid (1), protocatechuic acid (2), crustecdysone (14), daidzein (18) and icariside I (35), were basically stable in all samples across the years.ConcusionThe established method allowing to simultaneously determined 43 components with wide structural diversity and trace amounts will facilitate the quality control research of Chinese herbal spirits.
Highlights
Chinese medicinal wine, an alcoholic beverage, is commonly produced by soaking precious Chinese medicinal materials
Ultra-high performance liquid chromatography coupled to triple quadrupole mass spectrometry (UHPLC-QQQ-MS) operated in multiple reaction monitoring (MRM) mode is an effective quantification method owing to its well-known high sensitivity and specificity, which could avoid the interference from the background matrix [7,8,9]
An UHPLCQQQ-MS method was developed to simultaneously quantify 43 bioactive components in the Chinese herbal spirit samples produced by year 2014 and 2018, and their concentrations in different peoduction years were compared
Summary
An alcoholic beverage, is commonly produced by soaking precious Chinese medicinal materials. Its quality evaluation is greatly challenged by the enormous and complex components with great structural diversity and wide range of concentration distribution. An UHPLCQQQ-MS method was developed to simultaneously quantify 43 bioactive components in the Chinese herbal spirit samples produced by year 2014 and 2018, and their concentrations in different peoduction years were compared. The quality evaluation of Chinese herbal spirit is greatly challenged by the enormous and complex components with great structural diversity and wide range of concentration distribution
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