Abstract
7 patients (5%) experienced DF. On univariate analysis, only GTR was predictive of LF (HR Z 0.55, p Z 0.028). Extent of resection was not predictive of OS (HR Z 0.53, p Z 0.10). Among all patients, adjuvant radiation therapy did not improve LF (HR Z 0.79, p Z 0.53). Among patients with Simpson grade 4 or 5 resection, adjuvant RT significantly reduced LF (HRZ 0.38, pZ 0.036). Median time to LF in this subset was significantly prolonged by adjuvant RT (25 to 63 months). Adjuvant RT was not associated with time to local failure in patients who underwent GTR. Conclusions: Adjuvant RT improves time to local failure in patients with atypical meningiomas who undergo upfront Simpson grade 4 or 5 resection but not in patients who undergo upfront GTR. Author Disclosure: J. Kittel: None. J. Lee: None. N.M. Woody: None. Z. Amy: None. E.S. Murphy: None. G. Barnett: None. V. Michael: None. G. Stevens: None. J.H. Suh: K. Advisory Board; Varian Medical Systems. S.T. Chao: None.
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