Abstract

We report on a new small animal imaging platform for concomitant noninvasive mapping of the absorbed optical energy, acoustic reflectivity, speed of sound and acoustic attenuation in whole mice with submillimeter resolution. In vivo mouse imaging experiments revealed fine details on the organ parenchyma, vascularization, tissue reflectivity, density and stiffness. The newly developed synergistic multimodal combination offers unmatched capabilities for imaging diverse tissue properties and biomarkers with high resolution, penetration and contrast.

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