Simultaneous Multi-Slice Selective Constant-Time J-Resolved Spectroscopy for Measuring J Values

Abstract

Scalar coupling is an important parameter in nuclear magnetic resonance (NMR). The proton-proton coupling constant JH-H provides valuable information on molecular structure. However, determining JH-H value in complex coupling networks is still challenging. Here, we propose a method called simultaneous multi-slice selective constant-time J-resolved spectroscopy (SMS-SECTJRES) to measure JH-H values of all coupling networks of a molecule simultaneously in one experiment. In this method, gradient-encoded selective refocusing is used during a fixed evolution time, combined with echo planar spectroscopic imaging (EPSI) detection module to extract different selective J-edited spectra in different spatial positions. This new method is conducive to reveal coupling networks and the analysis of molecular structures.