Abstract
Measurement of gastric emptying is of clinical value for a range of conditions. Gamma scintigraphy (GS) has an established role, but the use of magnetic resonance imaging (MRI) has recently increased. Previous comparison studies between MRI and GS showed good correlation, but were performed on separate study days. In this study, the modalities were alternated rapidly allowing direct comparison with no intra-individual variability confounds. Twelve healthy participants consumed 400 g of Technetium-99m (99mTc)-labelled soup test meal (204 kcal) and were imaged at intervals for 150 min, alternating between MRI and GS. The time to empty half of the stomach contents (T1/2) and retention rate (RR) were calculated and data correlated. The average T1/2 was similar for MRI (44 ± 6 min) and GS (35 ± 4 min) with a moderate but significant difference between the two modalities (p < 0.004). The individual T1/2 values were measured, and MRI and GS showed a good positive correlation (r = 0.95, p < 0.0001), as well as all the RRs at each time point up to 120 min. Gastric emptying was measured for the first time by MRI and GS on the same day. This may help with translating the use of this simple meal, known to elicit reliable, physiological, and pathological gastrointestinal motor, peptide, and appetite responses.
Highlights
The importance of measuring gastric emptying in clinical and research arenas has long been recognised for a range of conditions including gastroparesis [1], dyspepsia [2] and dumping syndrome [3]
We aimed to evaluate the correlation of gastric emptying assessments between magnetic resonance imaging (MRI) and Gamma scintigraphy (GS) performed simultaneously on the same day in the same healthy participants
We examined of the correlation between the two imaging modalities using the half correlation between
Summary
The importance of measuring gastric emptying in clinical and research arenas has long been recognised for a range of conditions including gastroparesis [1], dyspepsia [2] and dumping syndrome [3]. Various techniques have been used over the years to measure gastric emptying. Gamma scintigraphy (GS) [8] has gained an established role and is very often considered the ‘gold standard’ for the quantitative assessment of gastric emptying [9]. The assessment of gastric emptying using magnetic resonance imaging (MRI) [10] has, recently increased [11,12] due to its lack of use of ionizing radiation, multi-planar ability, spatial resolution and richness of contrast mechanisms [13]. Gastric MRI and GS imaging inherently have different physical reporter parameters. MRI is based on the radio frequency signal arising from the spatial distribution of water hydrogen protons in a test meal; GS is based on the detection of gamma photons emitted by a radiolabelled test meal
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
