Abstract
Adrenal and plasma levels of corticosterone and 11-dehydrocorticosterone were measured in intact and stressed (laparotomy) rats by microcolumn high performance liquid chromatography. In contrast to humans, in rats plasma level of basic glucocorticoid is essentially higher than the level of its reversible metabolite. Acute stress (laparotomy) led to an increase in the adrenal concentration of 11-dehydrocorticosterone and plasma concentration of corticosterone, which was regarded as creation of a reserve corticosterone pool.
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