Abstract
A method using ultrahigh-performance liquid chromatography in combination with high-resolution time-of-flight mass spectrometry was developed for simultaneous identification and determination of the active ingredients (cetylpyridinium chloride, benzydamine, benzocaine, lidocaine, and tetracaine) in Septolete, Calgel, and Novosept Forte preparations. Analytes were identified using retention times, exact masses of ions, and agreement of isotopic distribution patterns (mSigma). The detection limits and limits of quantitation were 0.001 – 0.005 and 0.005 – 0.01 ng/mL, respectively, for all studied analytes. The ranges of determined contents were 0.01 – 50 and 0.005 – 10 ng/mL. The method was verified using actual preparations. The relative standard deviations of the analytical results were <0.05.
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