Abstract
Acetaminophen (I), guaifenesin (II), and dextromethorphan hydrobromide (III) were separated and quantitated simultaneously in cough syrup by high pressure liquid chromatography. A chemically bonded octadecylsilane stationary phase was used with a mobile phase of 45% (v/v) aqueous methanol. The mobile phase pH was stabilized to 4.2 by adding formic acid—ammonium formate buffer (∼0.4%). The internal standard was o-dinitrobenzene. Retention volumes were 4ml for I, 6ml for II, 11ml for the interfere standard, and 20ml for III. Inactive syrup components did not interfere permitting direct diluted sample injection. Results on active ingredients were essentially 100% of the claim, with standard deviations of ± 1.5, 1.2, and 2.1% for I,II,andIII, respectively.
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