Abstract
Two simple, accurate, precise and economical UV spectrophotometric methods, Multiple Linear Regression (MLR) and Principal Component Regression (PCR), were developed for the simultaneous estimation of dapaglifozin (DAPA) and saxagliptin (SAXA) in tablets. Beer’s law was obeyed in the concentration ranges of 10 – 50 μg/mL for DAPA and 5 – 25 μg/mL for SAXA. Synthetic mixtures containing two drugs were prepared to build the training set and validation set in the calibration range using D-optimal mixture design in phosphate buffer pH 6.8 and were recorded at six wavelengths in the range of 230 – 215 nm at intervals of Δλ = 3 nm. Both methods were validated as per ICH guidelines with respect to the accuracy and precision and found suitable for routine analysis of tablets containing DAPA and SAXA without separation.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
