Abstract

A novel, simple, rapid, precise, accurate, cost effective and reproducible spectroscopic method has been developed for simultaneous estimation of ambroxol HCl and olopatadine in formulated combined tablet dosage form. The method employs measurement of absorbance at two wavelengths, 246.nm and 298nm, of ambroxol and olopatadine respectively. Beer´s law obeyed in the concentration range of 12-72µg/ml and 2-16µg/ml for ambroxol and olopatadine respectively. The proposed method is recommended for routine analysis since it is rapid, simple, accurate, and also sensitive and specific. Results of percentage recovery studies confirmed the accuracy of the proposed method. The present uv spectroscopic method was validated following the ICH guideline.

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