Simultaneous Electrochemical Determination of Paracetamol and Diclofenac Based on Poly(diallyldimethylammonium chloride) Functionalized Graphene

Abstract

AbstractA simple but sensitive electrochemical method was proposed for simultaneous determination of paracetamol (PCT) and diclofenac (DCF) based on poly(diallyldimethylammonium chloride) (PDDA) functionalized graphene (GR). Although GR enhanced the electro‐oxidation peak currents of PCT and DCF, the peak potential difference between two drugs was reduced. By contrast, PDDA‐GR greatly increased the electrochemical currents of both analytes while provided well‐separated peak potentials. Thus, the voltammetric behavior and simultaneous electrochemical determination of PCT and DCF were investigated on PDDA‐GR. The applicability of the proposed method was verified when it was applied in determination of PCT and DCF in pharmaceuticals and lake water.