Abstract
<p class="PaperAbstract"><span lang="EN-US">A sensitive and economic voltammetric method was developed for the simultaneous determination of acetaminophen (AMP) and metoclopramide (MCP) using pre-treated graphite pencil electrode (PTGPE). Compared to a graphite pencil electrode, the pre-treated electrode showed an apparent shift of the oxidation potentials in the positive direction and a notable enhancement in the current responses for both AMP and MCP. Cyclic voltammetry (CV) was used to study the voltammetric behavior of the drugs, while differential pulse voltammetry (DPV) was used to determine AMP and MCP simultaneously. The dependence of the current on scan rate, pH and concentration was investigated to boost the experimental conditions for simultaneous determination. The calibration curves were obtained over the range of 0.1</span><span lang="EN-US">×</span><span lang="EN-US">10<sup>-7</sup> to 1.1</span><span lang="EN-US">×</span><span lang="EN-US">10<sup>-7</sup> M, the concentration of each of both the drugs was varied by keeping the other constant, and achieved lower detection limit of 3.25 nM for AMP and 1.16 nM for MCP. The developed method was found to be selective and rapid for the simultaneous determination of AMP and MCP. The proposed method was applied simultaneously in real samples and pharmaceutical samples, with satisfactory results.</span></p>
Highlights
The development of a sensitive, simple, reliable and rapid method for the determination of analyte is of great importance
Cyclic voltammetry Electrochemical response of a solution having homogeneous mixture of 1.0 μM of each AMP and MCP was estimated by cyclic voltammetry at 10 mV s-1 under optimized parameters using pre-treated graphite pencil electrode (PTGPE)
The peak intensities for PTGPE are better compared to the peak intensities obtained by using bare GPE
Summary
The development of a sensitive, simple, reliable and rapid method for the determination of analyte is of great importance. The pre-treated graphite pencil electrode (PTGPE) has been used as a biosensor in modern electroanalytical field due to its high mechanical rigidity, highly economical, good electrochemical reactivity, ease of modification, renewal of electrode and low background current [1,2]. PTGPE has good application in analysis of drugs, detection of traces of metal ions and doi:10.5599/jese.308.
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