Abstract
A glassy carbon electrode (GCE) was modified with a nanocomposite synthesized from electropolymerized L-cysteine (poly L-cys), gold nanoparticles (AuNPs), and B, N co-doped reduced graphene oxide (B, N-RGO). The sensor is depicted to enable the individual and simultaneous voltammetric determination of two purine derivatives, uric acid (UA) and xanthine (XA). Under the optimal conditions, the sensor displayed a good linear relationship between 3.0 nM and 3.0 µM for UA and 0.3 nM and 3.0 µM for XN in simultaneous determination. The limit of detection (LOD) and sensitivity are estimated to be 0.9 nM and 1.908 µA µM -1 cm−2, for UA and 90.0 pM and 0.846 µA µM−1 cm−2 for XA, respectively. The modified GCE demonstrates several benefits, including high sensitivity and selectivity, low LOD, high surface-to-volume ratio, and good electrocatalytic activity towards UA and XA. The sensor was used successfully for the simultaneous measurement of UA and XA in human blood serum samples.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
