Abstract
Design and synthesis of an efficient electrocatalyst for simultaneous determinationof gallic acid (GA) and uric acid (UA) is vital in thebiological field. Herein, we synthesized a new p-tert-butylcalix[4]arene-based metal-organic electrocatalyst (Mn-L@MC) by combining Mn-L (H4L = tetrakis[(2-biphenylcarboxyl)oxy]-p-tertbutylcalix[4]arene) and mesoporous carbon (MC) via a simple mechanical grinding method. Synergistic effect between Mn-L and MC made the Mn-L@MC composite behave high-efficiency electrocatalytic performance toward simultaneous detection of GA and UA. Under optimal experimental conditions, the Mn-L@MC-2 electrode material featured relatively wide linear range (0.5-90µM) for the two analytes, and low determination limits of 0.043µM for GA and 0.059µM for UA. The remarkable electrochemical detection behavior of Mn-L@MC-2 electrode material toward GA and UA are comparable to those known sensors containing precious metals. TheMn-L@MC-2 material exhibited highselectivity, superior reproducibility, and acceptable stability during the determinationof the two analytes. Thesensor was assembled to simultaneously detect GA and UA in healthy human urine with satisfactory recoveries.
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