Abstract
Non-melanoma skin cancer (NMSC) is one of the most common cutaneous malignancies, with an ever-increasing incidence rate worldwide [1]. Studies have shown an association between intermittent and chronic sunlight exposure and the development of BCC and SCC respectively [2]. UV radiation is a known carcinogen that can induce mutations in the p53 gene, known also as the guardian of the genome [3]. This can lead to persistent damage and failure to eliminate dysplastic cells as subsequent mechanisms like p21 and p16 activation fail to arrest cell cycle. Proapoptotic proteins such as BAK and BAX are also unable to activate programmed cell death, ultimately leading to the formation of precancerous lesions and NMSC [3, 4].
Highlights
Dr Nikhil Oliveira1 and Prof Dr Georgi Tchernev2* 1Student, Faculty of Medicine, Medical University of Sofia, Bulgaria
An 85-year-old Caucasian male presented to the clinic with multiple actinic keratoses alongside a suspicious tumour-like lesion on his head as well as a further lesion on his right lower leg
The surgical excisions were made under local anaesthesia and performed with clear margins (Fig. 2b-2d & 3a-3c) Histopathology confirmed squamous cell carcinoma (SCC) in the scalp as well as basal cell carcinoma (BCC) in the right lower leg respectively
Summary
Dr Nikhil Oliveira1 and Prof Dr Georgi Tchernev2* 1Student, Faculty of Medicine, Medical University of Sofia, Bulgaria. Studies have shown an association between intermittent and chronic sunlight exposure and the development of BCC and SCC respectively [2]. An 85-year-old Caucasian male presented to the clinic with multiple actinic keratoses alongside a suspicious tumour-like lesion on his head as well as a further lesion on his right lower leg.
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