Abstract
BackgroundGastrointestinal stromal tumors (GISTs) and adenocarcinoma are distinct neoplasms originating from different cell layers. Approximately 20% of patients with GIST develop other cancers.Case presentationWe report a case of the coexistence of adenocarcinoma and gastrointestinal stromal tumor (GIST). Gastric endoscopy showed the ulcerated tumor with bleeding along the lesser curvature of the proximal stomach and a submucosal nodule that measured about 3 cm in diameter in the lower part of the stomach body. Their pathological examination showed gastric cancer (poorly differentiated diffuse adenocarcinoma) and GIST (low-risk category). Further, immunohistochemical staining for C-kit and CD34 was positive, while that for SMA and S-100 was negative.ConclusionAlthough it is not easy to speculate on the coexistence of adenocarcinoma and GIST, pre-and post-operative diagnoses may be essential, and such cancer development is not considered to be unusual.
Highlights
Conclusion: it is not easy to speculate on the coexistence of adenocarcinoma and Gastrointestinal stromal tumors (GISTs), pre-and postoperative diagnoses may be essential, and such cancer development is not considered to be unusual
Gastrointestinal stromal tumors (GISTs) and adenocarcinoma are distinct neoplasms originating from different cell layers
Further histopathological examination of the submucosal nodule revealed GIST of the low-risk category [14], which was composed of cytologically bland spindle cells and showed a low mitotic index (< 5/50HPF)
Summary
Conclusion: it is not easy to speculate on the coexistence of adenocarcinoma and GIST, pre-and postoperative diagnoses may be essential, and such cancer development is not considered to be unusual. Gastrointestinal stromal tumors (GISTs) and adenocarcinoma are distinct neoplasms originating from different cell layers. Adenocarcinoma constitutes the most common type of gastric tumor, the synchronous development of a GIST is relatively rare [1,2,3,4,5,6].
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