Abstract
The decoction prepared from the roots of Ligusticum porteri Coulter & Rose (Apiaceae), also known as Mexican Angelica, is widely used for the treatment of gastritis, ulcers, diabetes, and different types of painful complaints, among others. Previous chemical studies of L. porteri revealed the presence of several phtalides including Z-ligustilide (1) and diligustilide (2), as the major active compounds. In the present investigation a suitable HPLC-UV procedure for simultaneous quantification of 1 and 2 in the crude drug of L. porteri was developed and validated. The method was found to be reliable, reproducible, and accurate. In addition, TLC, GC and MS profiles of the crude extract and essential oils as well as the microscopic characteristics of the roots were established. Altogether, these procedures will be valuable for quality control of the crude drug of L. porteri which is one of the most commercialized medicinal plants in Mexico. Acknowledgements: Supported by Grant DGAPA-UNAM (IN218110).
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