Abstract
ABSTRACT A method for the simultaneous determination of valsartan and hydrochlorothiazide in tablets is described. The procedure, based on the use of reversed-phase high-performance liquid chromatography, is linear in the concentration range 5.0-10.0 μg ml−1 for valsartan and 0.5-2.0 μg ml−1 for hydrochlorothiazide, is simple and rapid and allows accurate and precise results. The limit of detection was 1.0 μg ml−1 for valsartan and 0.05 μg ml−1 for hydrochlorothiazide.
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