Abstract
Background: Antihypertensive drugs are widely used to treat high blood pressure in patients. The aim of this study is to prepare various mixtures of valsartan and hydrochlorothiazide, to create a matrix effect in the drug, and to determine the determination of these active substances in drug samples after optimum conditions by first-order derivative spectroscopy method.
 Method: In the first-degree derivative spectrophotometry method applied, valsartan and hydrochlorothiazide were dissolved in methanol and 100 mgL-1 solutions were prepared, and then the mixtures of these solutions were determined in spectrophotometry. After mixing, tablet (drug) sample was prepared and absorbance values were recorded and the first derivative spectrophotometric method was applied to the values obtained.
 Results: As a result of the spectrophotometric determination of various mixtures of valsartan and hydrochlorothiazide used in the study, it was determined that the first-order derivative spectrophotometric method applied gave very consistent results.
 Conclusion: The first-order derivative spectrophotometry method used in the study can be easily applied in routine analyzes in drug research laboratories.
 
 Peer Review History: 
 Received: 15 July 2022; Revised: 10 August; Accepted: 7 September, Available online: 15 September 2022
 Academic Editor: Dr. A.A. Mgbahurike, University of Port Harcourt, Nigeria, amaka_mgbahurike@yahoo.com
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 Received file: Reviewer's Comments:
 Average Peer review marks at initial stage: 5.5/10
 Average Peer review marks at publication stage: 7.0/10
 Reviewers:
 Dr. U. S. Mahadeva Rao, Universiti Sultan Zainal Abidin, Terengganu Malaysia, raousm@gmail.com
 Prof. Cyprian Ogbonna ONYEJI, Obafemi Awolowo University, Ile-Ife, Nigeria, conyeji@oauife.edu.ng
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