Abstract
The offset-saturation experiment is shown to be a robust method for the simultaneous measurement of T1 and T2 NMR spin relaxation times. Application of the method to the measurement of T1 and T2 in a sample of distilled water shows that the relaxation times determined by the offset-saturation method are in good agreement with those obtained by conventional inversion-recovery and CPMG experiments for T1 and T2, respectively. Errors in the relaxation times from the nonlinear-least-squares fit to the experimental data are on the order of 5%, provided that the irradiating field γB2 is well calibrated and the sampling points are judiciously chosen. These errors are determined from the intersection of the appropriate parameter axis by the 95% confidence interval tangent. In the limit of small decoupler flip angles, the gated homodecouplers of high-resolution NMR spectrometers can be used as the RF irradiation source. The calibration of γB2 can be performed simply and precisely using the single-spin double-resonance experiment, which is shown to be a generalization of the Bloch-Siegert shift effect. A simple qualitative guideline for optimization of the choice of irradiation resonance offsets and preacquisition delay times is derived from the partial-derivative criteria outlined here.
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