Abstract
Paracetamol [1–5], N-(4-hydroxyphenyl)acetamide, is an analgesic commonly used in combination with many non-steroidal anti-inflammatory drugs (NSAID). Chlorzoxazone [3–5], 5-chloro-2(3H)-benzoxazole, is a skeletal muscle relaxant. Nimesulide [4], N-(4-nitro-2-phenoxyphenyl) methane sulfonamide, is an NSAID which also has antibacterial activity. One combination of these drugs, which contains 325 mg paracetamol, 375 mg chlorzoxazone, and 100 mg nimesulide, a very popular over-the-counter formulation used for pain control. A literature survey reveals that although many methods [1–3] have been reported for analysis of paracetamol, chlorzoxazone, and nimesulide, there is no report of a method for simultaneous determination of all three drugs by TLC or HPTLC.
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