Abstract
A method for the simultaneous determination of losartan potassium and hydrochlorothiazide in tablets is described. The procedure, based on the use of reversed-phase high-performance liquid chromatography, is linear in the concentration range 3.0–7.0 μg ml −1 for losartan and 0.5–2.0 μg ml −1 for hydrochlorothiazide, is simple and rapid and allows accurate and precise results. The limit of detection was 0.08 μg ml −1 for losartan and 0.05 μg ml −1 for hydrochlorothiazide.
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