Abstract
A simple, sensitive and quick assay to simultaneously determine lomefloxacin (LFLX) and ciprofloxacin (CPLX) had been developed by using zero-crossing first derivative constant wavelength synchronous spectrofluorimetry. Due to their similar molecule structures, it was difficult to analysis and determine LFLX and CPLX simultaneously by conventional fluorometry. In order to improve the sensitivity, aluminium ion was used to significantly enhance their endogenous fluorescent intensity. The different experimental parameters affecting the synchronous fluorescence intensity of the two fluoroquinolone drugs were carefully studied and optimized. The proposed method was successfully applied for the determination of the two drugs in milk samples.
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