Abstract
A new method to determine simultaneously the amount of furathiocarb and metabolites: carbofuran, 3-hydroxycarbofuran, and 3-ketocarbofuran in biological tissues such as liver and kidney is described. The method consists of extraction of samples with acetone, filtration, partition, purification of target analytes through a silica gel column and high-performance liquid chromatographic determination with post-column derivatization. Reasonable recoveries for routine analysis were obtained, and the limits of detection (LOD) with fluorescence detection were 0.2, 0.1, 0.1, and 0.2 mg L−1 for furathiocarb, carbofuran, 3-hydroxycarbofuran and 3-ketocarbofuran respectively, with a signal-to-noise ratio of 3. The present method was successfully applied to the dermal pharmacokinetic study of furathiocarb in Sprague-Dawley rats. Carbofuran and 3-hydroxycarbofuran were observed in liver while only carbofuran was detected in kidney.
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