Abstract
A sensitive UHPLC–MS/MS method to simultaneously determine fifteen heterocyclic aromatic amines (HAAs) was developed and applied analyze of human urine. The detection limit of the fifteen HAAs was 0.80–6.06pg/mL and the quantitation limit was 2.65–20.2pg/mL. The intra-day and inter-day precisions of all HAAs were ≤10%. Based on the high sensitivity and good precision, the method was successively applied to analyze the urine of smokers and nonsmokers. Ten HAAs were detected, analyzed and compared between the two groups, and the analytical results showed that cigarette smoke could increase the exposures to 2-amino-9H-pyrido[2,3-b]indole (AαC) and 2-amino-1,6-dimethylimidazo[4,5-b]-pyridine (DMIP). This work is the first report that ten HAAs were simultaneously detected, and is the first comprehensive study of HAA exposure induced by cigarette smoking.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
