Abstract
Urinary cortisol and corticosterone have been measured simultaneously without prior purification or chromatography using a fluorometric method which incorporates a correction for non-specific fluorescence. Non-corticoid fluorescence was corrected for by the introduction of a sample blank in which corticosteroid fluorescence has been altered by interaction with hydroxylamine. Daily excretion of cortisol in normal subjects from 18 to 120 μg with a mean of 51 ± 24 υg S.D. and of corticosteronre o to 16 μg with a mean of 3.0 ± 3.2 μg S.D. The demonstration of a circadian rhythm, low levels in patients with adrenocortical hypofunction, elevation in the third trimester of pregnancy and the expected responses to metyrapone and corticotropin illustrate the close correlation with adrenocortical activity.
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