Abstract
Present work was designed for the simultaneous determination of cetirizine in presence of atorvastatin, simvastatin, rosuvastatin or pravastatin using RP-HPLC method. The chromatographic separation achieved using mobile phase consisted of acetonitrile: water (75:25), monitored at 235 nm with a pH adjusted to 2.8. The linearity was assessed over the range of 2.5-100 µgmL-1 for all drugs. The applicability of the method was verified by the determination of cetirizine, atorvastatin, simvastatin, rosuvastatin and pravastatin in marketed formulations. The results of the method were validated statistically according to ICH guidelines. The recovery values for all the drugs in formulations were found to be 96-108 %. The parameters such as accuracy, precision, linearity, sensitivity (LOQ=0.01-0.07, LOD=0.003-0.02 µgmL-1) were found to be satisfactory. This method can be successfully used for the determination of these drugs in formulations and can be a useful tool for the routine analysis in laboratories.
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