Abstract
A simple, sensitive and reproducible reverse-phase high performance liquid chromatographic (RP-HPLC) method has been developed for simultaneous quantitative estimation of Atorvastatin calcium (ATOR) and Telmisartan (TELM) in the pharmaceutical formulations. Chromatographic separation was achieved on a 250 × 4.6 mm, 5μ, Waters symmetry column. The flow rate was 1ml/min and eluent was monitored by absorbance at 267 nm using a mixture of Methanol and Acetonitrile (pH 3.0
Highlights
Atorvastatin calcium (Fig. 1) is the calcium salt (2:1) trihydrate of [R-(R*, R*)]-2-(4-f luorophenyl)-b,d-dihydroxy-5-(1-methylethyl)3-phenyl-4[(phenylamino)carbonyl]-lH-pyrrole 1-heptanoic acid
Telmisartan (TELM) (Fig. 2) chemically described as 4[(1,4‐dimethyl‐2‐propyl(2,6‐bi‐ 1H‐benzimidazol]‐1‐yl)methyl][1,1‐biphenyl]‐2‐ carboxylic acid is a potent, long‐lasting nonpeptide antagonist of the angiotensin II (AT1) receptor that is indicated for the treatment of essential hypertension
The mean percentage recoveries obtained for Telmisartan and Atorvastatin were 99.90 and 99.66 respectively
Summary
Atorvastatin calcium (Fig. 1) is the calcium salt (2:1) trihydrate of [R-(R*, R*)]-2-(4-f luorophenyl)-b,d-dihydroxy-5-(1-methylethyl)3-phenyl-4[(phenylamino)carbonyl]-lH-pyrrole 1-heptanoic acid. Telmisartan (TELM) (Fig. 2) chemically described as 4[(1,4‐dimethyl‐2‐propyl(2,6‐bi‐ 1H‐benzimidazol]‐1‐yl)methyl][1,1‐biphenyl]‐2‐ carboxylic acid is a potent, long‐lasting nonpeptide antagonist of the angiotensin II (AT1) receptor that is indicated for the treatment of essential hypertension. A novel formulation commercially available in combination of Telmisartan and Atorvastatin calcium, benefits from the complementary modes of action of long‐lasting angiotensin receptor and antihyperlipidemic action. 2. Preparation of working standard:From the standard stock solution 10 ml is pipette out into 100 ml volumetric flask and made up the volume with mobile phase, having the concentration of 40 μg/ml of Telmisartan and 10 μg/ml of Atorvastatin. 3. Preparation of laboratory mixture:Accurately weighed quantities of TELM and ATOR (≈ 40 mg and ≈10 mg respectively) were mixed and transferred into a 100 ml volumetric flask, than dissolved with 25 ml of methanol and diluted to required volume with mobile phase, having the concentration of. An accurately measured 1.0 ml portion of the resultant solution was diluted to 10.0 ml with diluent to obtain a laboratory mixture having concentration similar to marketed formulation
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