Simultaneous determination of ascrobic, citric, and tartaric acids by potentiometric titration with PLS calibration

Abstract

The partial least squares (PLS) modeling method was used in the analysis of mixtures of ascorbic, citric, and tartaric acids by potentiometric titration. Binary mixtures of tartaric and citric acids, as well as ternary mixtures of tartaric, citric, and ascorbic acids, were titrated by sodium hydroxide pH-metrically. The linear relationship between the volumes of titrant and the concentrations of analytes was obtained by PLS regression. The designed model was then used to predict the concentrations of components in unknown samples. The practical utility of this method was demonstrated for the simultaneous determination of acids in binary and ternary mixture systems within concentration range from 4 × 10−4 to 2 × 10−3 M, and acceptable results were obtained.