Abstract
Androstenedione (Δ), Testosterone (T) and 5α-Dihydrotestosterone (DHT) concentrations in spermatic and peripheral venous blood obtained from twenty four men have been measured by radioimmunoassay. The concentrations (mean ± S.D.) of 5α-dihydrotestosterone in the spermatic vein (0.42 ± 0–33 μg/100ml) were higher than those found in the cubital vein (0.030 ± 0.012 μg/100ml). The blood plasma levels of 5α-dihydrotestosterone correlated significantly with testosterone levels in spermatic (P < 0.05) as well as in peripheral venous blood plasma (P < 0.01); on the other hand, 5α-dihydrotestosterone did not correlate with androstenedione. The results confirm the production of 5α-dihydrotestosterone by the human testis. Since there is a significant correlation between testosterone and 5α-dihydrotestosterone both in peripheral and in spermatic venous blood and an insignificant correlation between 5α-dihydrotestosterone and androstenedione, testosterone has been confirmed to be the most important precursor of 5α-dihydrotestosterone in the testis as well as in the other androgen target tissues.
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