Abstract
We have developed a highly sensitive assay for detecting TSH in human serum, capable of measuring as little as 1×10 −5 mU/ml. With this technic we can demonstrate TSH in sera from all normal subjects as well as in patients with hypopituitarism and Graves' disease where it has not previously been measurable. High levels are found in patients with myxedema. In addition, we are able to simultaneously demonstrate in sera from the majority of patients with Graves' disease a 7S gamma globulin with an affinity for the thyroid cell cytoplasm. The antigen for this substance is not destroyed by polar solvents, its presence is not correlatable with thyroid antibodies, and it occurs independent of the presence of infiltrative exophthalmos or pretibial myxedema. The presence of this material can be correlated with long acting thyroid stimulator activity in the McKenzie assay and appears to be related to or identical with LATS.
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