Abstract
Three hundred and seventy-one serum samples from 170 children with congenital or natally or post-natally acquired cytomegalovirus (CMV) infections, demonstrated by virus isolation from urine and/or saliva, were tested for specific IgM and IgA antibodies by an indirect enzyme immunoassay. Among infants with congenital CMV infection, IgM was detected more frequently than IgA ( P < 0·001). In sera obtained 1 month post-birth, the IgA was more frequently raised ( P < 0·05) than the IgM. Of 24 infants with perinatally-acquired CMV infection, 22 had IgM; of these, 41·7% had also IgA. Among 46 children with CMV-associated acute diseases, 26·1% of which showed no IgM or IgA, IgA was detected more frequently but not significantly ( P > 0·05) than IgM. Among 53 children with recurrent or chronic cytomegaloviral diseases, IgA was detected in 11 (20·7%) and IgM in two (3·8%) patients ( P < 0·001). The simultaneous detection of specific IgM and IgA antibodies is better than only IgM for rapid serological diagnosis of both congenital, and post-natally acquired CMV infections.
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